The Gasch Lab, in collaboration with Megan McClean’s Lab, at the University of Wisconsin-Madison seeks an ambitious postdoctoral fellow to lead a funded project investigating heterogenetity in cellular signaling during stress responses.
We are using cutting edge techniques in single-cell RNA sequencing (scRNA-seq) and live-cell imaging to explore heterogeneity and dynamics in stress-responsive signaling in Saccharomyces cerevisiae. This is a funded project combining predictions from network inference (Chasman and Ho et al., 2014, Molecular Systems Biology) and single-cell analysis (Gasch and Yu et al., 2017, PLoS Biology) to investigate how different regulatory branches in the yeast signaling network affect noise, dynamics, and robustness in eukaryotic stress-responsive signaling. Results of this work will have important implications for signaling dynamics, buffering in signal transduction, and coordination of disparate cellular responses to stress. Because many aspects of the stress-activated signaling network in yeast are conserved in humans and have links to cancer signaling (Ho & Gasch, 2015, Current Genetics), results will have broader implication for stress-activated signaling in disease. The position is an excellent opportunity to combine bench analysis with computational/mathematical modeling in a collaborative environment.
The project will combine yeast genetics, molecular biology, live cell imaging of transcription factor localization dynamics and potentially single-cell RNA sequencing along with computational and mathematical modeling. The ideal candidate will have wet-bench experience in genetics, genomics or related fields. Past experience generating and analyzing large datasets and/or performing mathematical modeling is a plus but not required.
Candidates should have:
- Been recently awarded or soon to be awarded a Ph.D. in genetics, biochemistry, molecular biology, computational biology, or similar field.
- Demonstrated productivity through first author publications or preprints
- Be highly motivated, independent, and driven
- Be interested in joining a collaborative research group in the Gasch Lab
The Gasch Lab is housed within the Laboratory of Genetics at the University of Wisconsin-Madison, across the street from the McClean Lab in the Department of Biomedical Engineering. UW-Madison is a vibrant community with a strong culture of interdisciplinary collaboration and communication. There are many opportunities for research and professional development. Madison is an exceptional place to live and is frequently voted one of the best cities in the country.
To apply
Intersted candidates should email a CV, statement of research interests, manuscript preprints (if yet to be published), and contact information for three references to Audrey Gasch (agasch@wisc.edu).
We welcome and encourage women, members of underrepresented minority groups, and individuals with disabilities to apply.